Inti Guttu revolves around the story of a teenager Kalyani, who loses her cherished mother Madhuri in an accident and is compelled to live with her step-mother Anupama. However, Kalyani despises Anupama and refuses to accept her. Can Anupama win Kalyani’s heart with her kindness? How they develop a deep unconventional bond and journey beyond the ties of blood forms the rest of the remarkable family story.